Population
tsA-201 cells transiently expressing rat brain rIIA Na+ channel alpha subunits and rat heart rH1 Na+ channel…
Comparison
Site-directed mutagenesis and application of… vs Wild-type channels and alternative sides of…
Design
Preclinical
Authors
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Residue 1755 controls extracellular access to the cardiac Na+ channel site; leaves open human translation and antiarrhythmic applications.
This study identifies specific amino acid residues (Thr-1755 and Phe-1762) in the cardiac Na+ channel that determine extracellular access and binding of local anesthetic and antiarrhythmic drugs.
Qu et al. (1995) studied this question.
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