Population
6 normal thin ventricular epicardial tissue strips and 18 strips removed from the infarcted regions of dogs…
Comparison
Heptanol added to the tissue bath at… vs Control recordings
Design
Preclinical
Authors
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Implicates gap junction dysfunction in postinfarct conduction slowing; hypothesis-generating for targeted therapies, not ready for clinical use.
Heptanol-induced cellular uncoupling demonstrates that slow and dissociated conduction in infarcted myocardium is likely due to abnormal gap junctional distribution or function.
Spear et al. (1990) studied this question.
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