Key result
Combined fragmented QRS and reduced GLS predict the presence and location of >70% coronary stenosis.
Why the study?
The study investigated whether combining fragmented QRS on surface ECG with reduced myocardial strain could predict significant coronary artery disease.
Does the combination of fQRS and reduced myocardial strain predict significant coronary artery stenosis in patients undergoing coronary angiography?
Case-Control (n=110)
Single-blind
No
Does the combination of fQRS and reduced myocardial strain predict significant coronary artery stenosis in patients undergoing coronary angiography?
Answers are grounded in this paper and cite their sources.
The combination of fQRS on ECG and reduced myocardial strain on echocardiography can help predict the presence and location of significant coronary artery stenosis.
Introduction: Fragmented QRS (fQRS) on a 12-lead ECG indicates electrical conduction disruption due to various cardiac issues, including coronary artery disease (CAD). This study investigated whether combining fQRS and reduced myocardial strain could predict significant CAD. Methods: We conducted a cross-sectional study on patients with fQRS on surface ECG who underwent coronary angiography. The left ventricular strain was assessed using 2D speckle-tracking echocardiography. Results: We enrolled 55 patients with fQRS and significant CAD (≥70% coronary artery stenosis) and 55 control patients (≤30% stenosis). The strain was significantly reduced in segments with fQRS and significant CAD compared with the control group. Conclusion: In patients with CAD, the combination of fQRS in any ECG lead and reduced strain can predict the presence and location of a coronary artery with greater than 70% stenosis.
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Tabatabaei et al. (2024) conducted a case-control in Suspected coronary artery disease (n=110). Fragmented QRS combined with strain echocardiography vs. Patients with fQRS but normal coronary arteries or <30% stenosis was evaluated on Global longitudinal strain in the basal anteroseptal segment among patients with fQRS in leads V4-V6 (p=0.009). The combination of fragmented QRS on any ECG lead and reduced global longitudinal strain significantly predicted the presence and location of >70% coronary artery stenosis.
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