Why the study?
Disrupted fatty acid metabolism is a key feature in heart failure, where decreased fatty acid oxidation and accumulation of excess lipid moieties lead to cardiac lipotoxicity.
This review highlights the role of disrupted fatty acid metabolism in heart failure and identifies potential metabolic targets for new therapeutic strategies.
Does not alter current HF management; leaves open targeted trials of fatty acid modulators.
Disrupted fatty acid metabolism is one of the most important metabolic features in heart failure. The heart obtains energy from fatty acids via oxidation. However, heart failure results in markedly decreased fatty acid oxidation and is accompanied by the accumulation of excess lipid moieties that lead to cardiac lipotoxicity. Herein, we summarized and discussed the current understanding of the integrated regulation of fatty acid metabolism (including fatty acid uptake, lipogenesis, lipolysis, and fatty acid oxidation) in the pathogenesis of heart failure. The functions of many enzymes and regulatory factors in fatty acid homeostasis were characterized. We reviewed their contributions to the development of heart failure and highlighted potential targets that may serve as promising new therapeutic strategies.
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Li et al. (2023) studied this question.
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