September 1, 2021Minerva Cardiology and Angiology
Left ventricular concentric remodeling and impaired cardiorespiratory fitness in patients with heart failure and preserved ejection fraction
Why the study?
Although LV concentric remodeling is a negative prognostic factor in HFpEF, its contribution to cardiorespiratory fitness remains unknown.
Does left ventricular concentric remodeling correlate with impaired cardiorespiratory fitness in patients with HFpEF?
Population
23 patients with HFpEF undergoing treadmill SPECT-MPI and CPX
Design
Retrospective analysis
Authors
Discussion
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Member takes
Implication
Concentric remodeling may limit fitness in HFpEF; hypothesis-generating and requires prospective validation.
Structured PICO
Does left ventricular concentric remodeling correlate with impaired cardiorespiratory fitness in patients with HFpEF?
P
Population
23 patients with heart failure and preserved ejection fraction (HFpEF), mean age 50 (±7.3) years, 83% women, 65% black, obese (BMI 39.7 ±6.0 kg/m2).
O
Outcome
Correlation between postexercise left ventricular volumes (LVEDVi, LVESVi) and measures of cardiorespiratory fitness (peak VO2, OUES, O2 pulse)surrogate
In patients with HFpEF, reduced left ventricular volumes postexercise correlate with worse cardiorespiratory fitness, suggesting concentric remodeling contributes to exercise intolerance.
Cite This Study
Heizer et al. (2021) studied this question.