Key result
Aged male rats exhibit greater arrhythmia susceptibility than females, driven by prolonged activation and repolarization.
Why the study?
The aged heart is more prone to develop cardiovascular diseases including arrhythmias, but sex-specific electrophysiological alterations associated with aging require characterization.
Suggests greater male vulnerability to age-related arrhythmias; leaves open human translation and targeted interventions.
Aged heart is more prone to develop cardiovascular diseases including arrhythmias. The age-related electrical remodeling of the heart results in specific electrophysiological alterations in male and female rats. Males could experience more challenging adaptations as they age. They show prolongations of atrial and ventricular activation, ventricular repolarization, and refractoriness. Aged females display alterations in ventricular activation. Arrhythmias are more likely to occur in aged animals with males being more susceptible to spontaneous and induced arrhythmias.
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Statello et al. (2025) studied Arrhythmias. Male sex vs. Female sex was evaluated on Susceptibility to spontaneous and induced arrhythmias. Aged male rats were more susceptible to spontaneous and induced arrhythmias than aged females, exhibiting prolongations of atrial and ventricular activation, repolarization, and refractoriness.
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