Why the study?
Does physiological aging alter heart rate and atrioventricular conduction in a rat model?
Population
Langendorff-perfused hearts from Fischer 344 rats, including mature, middle-aged, and senescent groups.
Comparison
Physiological aging, with additional testing… vs Mature rats (4-6 months old).
Design
Preclinical
Authors
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Rat model links aging to intrinsic conduction slowing; hypothesis-generating and should not yet inform human practice.
Does physiological aging alter heart rate and atrioventricular conduction in a rat model?
Physiological aging in a rat model is associated with intrinsic decreases in heart rate, prolonged AV conduction, and increased collagen deposition in the conduction system.
Schmidlin et al. (1992) studied this question.
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