Why the study?
Does aging affect the electrophysiologic and hemodynamic responses to nifedipine in isolated rat hearts?
Population
Isolated Langendorff-perfused hearts from 24 male Fischer 344 rats
Comparison
Nifedipine perfusion at concentrations of 25… vs Baseline and comparison between mature and…
Design
Preclinical
Follow-up
25 minutes
Authors
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Nifedipine may depress atrial rate and contractility more in senescent hearts; leaves open age-specific effects in humans.
Does aging affect the electrophysiologic and hemodynamic responses to nifedipine in isolated rat hearts?
Senescent rat hearts exhibit greater depression of atrial rate and myocardial contractility (peak dP/dt) in response to nifedipine compared to mature hearts.
Schmidlin et al. (1992) studied this question.
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