Key result
GP ablation yields inconsistent clinical results for AF despite theoretically suppressing autonomic hyperactivity.
Why the study?
Does ganglionated plexi (GP) ablation prevent paroxysmal atrial fibrillation?
Does ganglionated plexi (GP) ablation prevent paroxysmal atrial fibrillation?
While GP ablation has a strong theoretical basis for treating paroxysmal AF by targeting autonomic hyperactivity, its clinical efficacy remains inconsistent and requires further investigation.
GP ablation should not change practice for paroxysmal AF; leaves open the efficacy of autonomic modulation in definitive trials.
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Kenzo Hirao (2016) conducted a review in Atrial Fibrillation. Ganglionated plexi (GP) ablation was evaluated. Ganglionated plexi (GP) ablation theoretically suppresses hyperactive intrinsic cardiac autonomic nervous system to treat atrial fibrillation, but clinical results remain inconsistent and require further research.
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