What question did this study set out to answer?

The study aims to compare the efficacy and tolerance of neoadjuvant endocrine therapy versus chemotherapy in postmenopausal women with ER-positive breast cancer.

July 15, 2004Journal of Clinical Oncology

The relative efficacy of neoadjuvant endocrine therapy vs chemotherapy in postmenopausal women with ER- positive breast cancer

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Authors

SVSemiglazov VfInstitute of Oncology NN Petrov VSVladimir SemiglazovInstitute of Oncology NN Petrov ВИВ Г ИвановIzhevsk State Medical Academy

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Implication

Randomized trial compares outcomes of neoadjuvant endocrine therapy and chemotherapy in postmenopausal women, suggesting preferred approaches for low-toxicity treatment.

Key Points

The study aims to compare the efficacy and tolerance of neoadjuvant endocrine therapy versus chemotherapy in postmenopausal women with ER-positive breast cancer.
121 postmenopausal women with ER(+) and/or PgR(+) breast cancer received either neoadjuvant chemotherapy or endocrine therapy.
Participants were assigned to receive 4 cycles of chemotherapy or 3 months of an aromatase inhibitor (anastrazole).
Endpoints included overall response rates and qualification for breast-conserving surgery.
Overall response rates were statistically similar between chemotherapy and anastrozole groups (p > 0.05).
A higher tendency for breast-conserving surgery was observed in the anastrozole group (37.9%) compared to chemotherapy (20.6%), p=0.054.
Local recurrence rates were comparable between both treatment arms (3.2% for chemotherapy and 3.4% for endocrine therapy).

Cite This Study

Vf et al. (2004) studied this question.

synapsesocial.com/papers/6a0fbf3092676d5461fd0920 https://doi.org/10.1200/jco.2004.22.90140.519

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Implication

Randomized trial compares outcomes of neoadjuvant endocrine therapy and chemotherapy in postmenopausal women, suggesting preferred approaches for low-toxicity treatment.

The relative efficacy of neoadjuvant endocrine therapy vs chemotherapy in postmenopausal women with ER- positive breast cancer

Discussion

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Implication

Key Points

Cite This Study

The relative efficacy of neoadjuvant endocrine therapy vs chemotherapy in postmenopausal women with ER- positive breast cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

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