Prognostic importance of strain and strain rate after acute myocardial infarction
Key result
Global strain > -15.1% after AMI is linked to ~350% higher all-cause mortality.
- HR 4.5
- 95% CI 2.1-9.7
- n=659
Why the study?
Strain and strain rate are novel parameters reflecting LV function, and their prognostic importance after AMI needed assessment.
Do echocardiographic strain and strain rate provide prognostic information superior to traditional parameters in patients after acute myocardial infarction?
Population
659 patients after AMI
Comparison
Strain and strain rate vs traditional LV function parameters (LVEF and WMSI)
Design
Cohort study with baseline echocardiography
Authors
Discussion
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Member takes
Implication
Strain and strain rate may refine post-AMI risk stratification beyond LVEF; leaves open need for prospective validation before practice change.
Study Design
Type
Cohort (n=659)
Structured PICO
Do echocardiographic strain and strain rate provide prognostic information superior to traditional parameters in patients after acute myocardial infarction?
P
Population
659 patients evaluated after acute myocardial infarction to assess the prognostic value of echocardiographic strain and strain rate.
E
Exposure
Echocardiographic assessment of left ventricular strain and strain rate
C
Comparator
Traditional echocardiographic parameters (LV ejection fraction and wall motion score index)
O
Outcome
All-cause mortalityhard clinical
Main Result
Hazard Ratio: 4.5 (95% CI 2.1–9.7)
Echocardiographic strain and strain rate are strong, independent predictors of long-term outcomes after AMI, superior to traditional LVEF and WMSI.
Cite This Study
Antoni et al. (2010) conducted a cohort in Acute myocardial infarction (n=659). Global strain > -15.1% and strain rate > -1.06 s(-1) was evaluated on All-cause mortality (HR 4.5, 95% CI 2.1-9.7). Global strain > -15.1% and strain rate > -1.06 s(-1) after AMI were strongly associated with increased all-cause mortality (HR 4.5, 95% CI 2.1-9.7 and HR 4.4, 95% CI 2.0-9.5, respectively).