Key result
Adding echocardiographic strain to ejection fraction significantly improved the 5-year AUC for predicting adverse outcomes from 0.638 to 0.700 (P=0.001).
Why the study?
Does speckle-tracking analysis of left ventricular strain improve risk prediction beyond ejection fraction in patients with chronic systolic heart failure?
Population
416 patients with chronic systolic heart failure
Comparison
Speckle-tracking analyses of left ventricular… vs Ejection fraction (EF) alone
Design
Cohort
Follow-up
maximum 8.9 years
Authors
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Speckle-tracking strain may refine HF prognosis; hypothesis-generating and requires prospective validation before clinical use.
Cohort (n=416)
Does speckle-tracking analysis of left ventricular strain improve risk prediction beyond ejection fraction in patients with chronic systolic heart failure?
Effect estimate: ≈ 2-fold increased risk
p-value: p=<0.05
Echocardiographic strain provides incremental prognostic value beyond ejection fraction for predicting adverse outcomes in chronic systolic heart failure.
Zhang et al. (2014) conducted a cohort in chronic systolic heart failure (n=416). Echocardiographic strain and strain rate vs. Ejection fraction alone / reference group was evaluated on All-cause mortality, cardiac transplantation, and ventricular-assist device placement (≈ 2-fold increased risk, p=<0.05). Adding echocardiographic strain to ejection fraction significantly improved the 5-year AUC for predicting adverse outcomes from 0.638 to 0.700 (P=0.001).
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