Why the study?
Elevated levels of coagulation factors are associated with existing and newly diagnosed AF, prompting a summary of the role of coagulation in AF pathogenesis.
What is the role of coagulation factors and markers in the pathogenesis of atrial fibrillation?
What is the role of coagulation factors and markers in the pathogenesis of atrial fibrillation?
This review highlights that coagulation irregularities and elevated levels of various coagulation factors play a significant role in the pathogenesis of atrial fibrillation.
May inform mechanistic research on AF; does not support changing anticoagulation based on coagulation markers.
The existing literature highlights the presence of numerous coagulation factors and markers. Elevated levels of coagulation factors are associated with both existing and newly diagnosed cases of atrial fibrillation (AF). However, this article summarizes the role of coagulation in the pathogenesis of AF, which includes fibrinogen and fibrin, prothrombin, thrombomodulin, soluble urokinase plasminogen activator receptor, von Willebrand factor, P-selectin, D-dimer, plasminogen activator inhibitor-1, and platelet activation. Coagulation irregularities play a significant role in the pathogenesis of AF.
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Rafaqat et al. (2024) studied this question.
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