Key result
Increased circulating hemostatic factors, such as platelet factor-4 (SMD 1.72; 95% CI 0.96-2.49) and D-dimer (SMD 1.82; 95% CI 1.38-2.26), are significantly associated with atrial fibrillation.
Why the study?
Are elevated circulating hemostatic markers associated with atrial fibrillation?
Population
59 observational studies comparing patients with atrial fibrillation (cases) to controls.
Comparison
Circulating hemostatic markers vs Controls without atrial fibrillation
Design
Meta-analysis
Authors
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Does not support routine testing in AF; confirms prothrombotic state but leaves open predictive value and therapeutic targeting.
Meta-Analysis
Are elevated circulating hemostatic markers associated with atrial fibrillation?
Standardized Mean Difference: 1.72 (95% CI 0.96–2.49)
This meta-analysis confirms a prothrombotic state in atrial fibrillation, characterized by significantly elevated markers of platelet and coagulation activation as well as endothelial dysfunction.
Wu et al. (2015) conducted a meta-analysis in Atrial Fibrillation. Hemostatic markers vs. Controls was evaluated on Platelet factor-4 levels in AF cases vs controls (SMD 1.72, 95% CI 0.96-2.49). Increased circulating hemostatic factors, such as platelet factor-4 (SMD 1.72; 95% CI 0.96-2.49) and D-dimer (SMD 1.82; 95% CI 1.38-2.26), are significantly associated with atrial fibrillation.
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