Why the study?
Does antihypertensive treatment reduce mortality and cardiovascular morbidity in patients with diabetes mellitus at different baseline blood pressure levels?
Population
73,738 participants with diabetes mellitus (mostly type 2) from 49 randomized controlled trials
Comparison
Antihypertensive treatment for 12 months or more vs Placebo, one agent, or different blood pressure…
Design
Meta-analysis
Follow-up
≥12 months
Authors
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Supports antihypertensives in diabetes only for baseline SBP >140 mm Hg; challenges lower treatment thresholds.
Does antihypertensive treatment reduce mortality and cardiovascular morbidity in patients with diabetes mellitus at different baseline blood pressure levels?
Antihypertensive treatment in patients with diabetes reduces mortality and cardiovascular events when baseline SBP is >140 mm Hg, but may increase cardiovascular death if baseline SBP is <140 mm Hg.
Brunström et al. (2016) studied this question.