What question did this study set out to answer?

To assess the benefits of antihypertensive therapy in patients with both high blood pressure and diabetes mellitus.

September 11, 2000Archives of Internal Medicine

High Blood Pressure and Diabetes Mellitus

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Why the study?

Does intensive antihypertensive therapy reduce cardiovascular morbidity and mortality in hypertensive patients with diabetes mellitus?

Population

Hypertensive patients with diabetes mellitus from prospective randomized studies of >12 months duration

Design

Systematic_review

Follow-up

>12 months

Authors

EGEhud GrossmanPreventive Cardiology FMFranz H. MesserliPreventive Cardiology UGUri GoldbourtGeneral / Preventive / Lipids

Discussion

Member takes

Implication

Intensive BP control benefits diabetic hypertensives; reinforces randomized evidence for any major class and combination regimens in most patients.

Key Points

To assess the benefits of antihypertensive therapy in patients with both high blood pressure and diabetes mellitus.
Conducted a MEDLINE search for English-language articles on diabetes, hypertension, and therapy until June 1999.
Included prospective randomized studies lasting over 12 months that evaluated drug treatment effects on morbidity and mortality in diabetic hypertensive patients.
Analyzed the risk associated with diabetes and hypertension and their treatment outcomes.
Diabetes mellitus doubled the risk of cardiovascular events and cardiovascular mortality in hypertensive patients (RR 1.73-2.77 for events, 2.25-3.66 for mortality).
Intensive blood pressure control (<130/85 mm Hg) was beneficial in diabetic hypertensive patients.
Combination therapy was required in over 60% of patients to effectively control blood pressure.

Structured PICO

Does intensive antihypertensive therapy reduce cardiovascular morbidity and mortality in hypertensive patients with diabetes mellitus?

Population

Hypertensive patients with diabetes mellitus from prospective randomized studies of >12 months duration

Intervention

Antihypertensive therapy (diuretics, beta-blockers, angiotensin-converting enzyme inhibitors, or calcium antagonists) targeting intensive blood pressure control to <130/85 mm Hg

Outcome

Cardiovascular morbidity and mortality (cardiovascular events, cardiovascular mortality, and total mortality)hard clinical

Intensive blood pressure control (target <130/85 mm Hg) using any major antihypertensive class significantly reduces cardiovascular morbidity and mortality in patients with diabetes and hypertension.

Cite This Study

Grossman et al. (2000) studied this question.

synapsesocial.com/papers/6a6fda736c240de38cdb9a25 https://doi.org/10.1001/archinte.160.16.2447

Topics

Hypertension management

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Implication

Intensive BP control benefits diabetic hypertensives; reinforces randomized evidence for any major class and combination regimens in most patients.

High Blood Pressure and Diabetes Mellitus

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

High Blood Pressure and Diabetes Mellitus

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Topics

Also Consider