Key result
Combination therapy with calcium channel blockers plus renin-angiotensin system-blocking agents reduces the risk of major cardiovascular events and provides greater renoprotection than diuretic-based combinations.
Why the study?
Does combination therapy with calcium channel blockers plus renin-angiotensin system-blocking agents reduce major cardiovascular events in hypertensive patients with diabetes mellitus?
Population
Hypertensive patients with diabetes mellitus
Comparison
Combination therapy of calcium channel blockers… vs Diuretic-based combinations
Design
Review
Authors
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May support CCB-RAS blocker combinations in diabetic hypertension; leaves open need for dedicated RCTs versus diuretics.
Does combination therapy with calcium channel blockers plus renin-angiotensin system-blocking agents reduce major cardiovascular events in hypertensive patients with diabetes mellitus?
Combination therapy with calcium channel blockers and renin-angiotensin system blockers may be superior to diuretic-based combinations for cardiovascular and renal protection in diabetic hypertensive patients.
Reboldi et al. (2009) conducted a review in Hypertension and diabetes mellitus. Calcium channel blockers plus renin-angiotensin system-blocking agents vs. Diuretic-based combinations was evaluated on Major cardiovascular events, renoprotection, and metabolic outcomes. Combination therapy with calcium channel blockers plus renin-angiotensin system-blocking agents reduces the risk of major cardiovascular events and provides greater renoprotection than diuretic-based combinations.
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