Relationship of Kidney Injury Biomarkers with Long-Term Cardiovascular Outcomes after Cardiac Surgery
Why the study?
Are postoperative kidney and cardiac injury biomarkers associated with long-term cardiovascular events or death in adults undergoing cardiac surgery?
Population
968 adults undergoing cardiac surgery
Comparison
Measurement of urine kidney injury biomarkers… vs Patients without postsurgical AKI
Design
Cohort
Follow-up
median 3.8 years
Authors
Discussion
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Member takes
Implication
Postoperative AKI signals long-term CV risk mainly via cardiac stress markers; supports mediation-focused research over isolated renal pathways in observational data.
Structured PICO
Are postoperative kidney and cardiac injury biomarkers associated with long-term cardiovascular events or death in adults undergoing cardiac surgery?
P
Population
968 adults undergoing cardiac surgery
I
Intervention
Measurement of urine kidney injury biomarkers (IL-18, NGAL, KIM-1, L-FABP, albumin) and plasma cardiac injury biomarkers (NT-proBNP, H-FABP, hs-cTnT, cTnI, CK-MB) on postoperative days 1-3, and clinical AKI assessment
C
Comparator
Patients without postsurgical AKI
O
Outcome
Composite of long-term cardiovascular events or deathcomposite
Clinical AKI after cardiac surgery predicts long-term adverse CV outcomes primarily as a marker of concurrent cardiovascular stress rather than through an independent renal pathway.
Cite This Study
Parikh et al. (2017) studied this question.