Results from the TRIBE-AKI Study found associations between post-operative blood biomarkers and risk of chronic kidney disease after cardiac surgery
Why the study?
Patients undergoing cardiac surgery face intense physiologic stress, and peri-operative biomarkers may help identify those at higher risk for adverse long-term kidney outcomes.
Are post-operative blood biomarkers associated with the development or progression of chronic kidney disease in adult patients undergoing cardiac surgery?
Population
613 adult patients undergoing cardiac surgery in Canada, with a replication cohort of 310 US patients
Comparison
Associations of 40 blood and urinary biomarkers with CKD incidence or progression
Design
Prospective cohort sub-study with a replication cohort
Follow-up
Median follow-up of 5.6 years
Authors
Discussion
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Member takes
Implication
May aid post-cardiac surgery CKD risk stratification; extends observational associations but remains hypothesis-generating.
Structured PICO
Are post-operative blood biomarkers associated with the development or progression of chronic kidney disease in adult patients undergoing cardiac surgery?
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Population
923 adult patients undergoing cardiac surgery (613 in Canadian primary cohort, 310 in US replication cohort)
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Intervention
Post-operative blood and urinary biomarkers (40 tested, including basic fibroblast growth factor, Kidney Injury Molecule-1, N-terminal pro-B-type natriuretic peptide, and tumor necrosis factor receptor 1)
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Outcome
Composite outcome of CKD incidence (25% reduction in eGFR and eGFR <60 mL/min/1.73m2 in those with baseline eGFR >60) or CKD progression (50% reduction in eGFR or eGFR <15 in those with baseline eGFR <60)composite
Elevated post-operative levels of specific blood biomarkers following cardiac surgery are independently associated with the development and progression of chronic kidney disease.
Cite This Study
Menez et al. (2020) studied this question.