June 1, 2016Circulation Cardiovascular Interventions
Long-Term Mortality in Patients With Radiation-Associated Coronary Artery Disease Treated With Percutaneous Coronary Intervention
Why the study?
Does previous external beam radiation therapy increase long-term mortality in patients undergoing percutaneous coronary intervention?
Population
314 patients treated with percutaneous coronary intervention, comprising 157 patients with previous external…
Comparison
Percutaneous coronary intervention in patients… vs Percutaneous coronary intervention in matched…
Design
Cohort
Follow-up
6.6±5.5 years
Authors
Discussion
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Member takes
Implication
Prior radiation therapy associated with higher post-PCI mortality; leaves open whether it should modify revascularization strategy or surveillance.
Structured PICO
Does previous external beam radiation therapy increase long-term mortality in patients undergoing percutaneous coronary intervention?
P
Population
314 patients (mean age 65.2±11.4 years, 74% women) treated with percutaneous coronary intervention (PCI), comprising 157 patients with previous external beam radiation therapy (XRT) matched 1:1 with 157 comparison patients with atherosclerotic coronary artery disease without previous XRT.
I
Intervention
Percutaneous coronary intervention (PCI) in patients with radiation-associated coronary artery disease (previous external beam radiation therapy).
C
Comparator
Percutaneous coronary intervention (PCI) in matched patients with typical atherosclerotic coronary artery disease without previous external beam radiation therapy.
O
Outcome
All-cause mortalityhard clinical
Patients with radiation-associated coronary artery disease undergoing PCI have a significantly higher risk of long-term all-cause and cardiovascular mortality compared to matched patients with typical atherosclerotic CAD.
Cite This Study
Reed et al. (2016) studied this question.