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December 16, 2025Primary care diabetes2 citationsOpen Access

Routine HbA1c monitoring and cardiovascular outcomes in diabetes: Evidence from a large Spanish cohort

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DODomingo Orozco‐BeltránSSSamuel SeiduJQJosé A. Quesada

Structured PICO

Does missing HbA1c values at diagnosis increase the risk of major cardiovascular events or death in people with newly diagnosed diabetes?

P
Population
People with newly diagnosed diabetes from a large Spanish cohort
I
Intervention
Missing HbA1c values at diagnosis
C
Comparator
Recorded HbA1c values (< 7 %, 7 %-8 %, > 8 %)
O
Outcome
Major cardiovascular events or death from all causescomposite

Missing HbA1c values at diagnosis in newly diagnosed diabetes is a strong prognostic indicator for increased risk of major cardiovascular events or death, likely reflecting suboptimal clinical follow-up.

Abstract

AIM: values and the occurrence of major cardiovascular events or death from all causes. METHODS: ( 8 %, missing). Cox models were fitted. RESULTS: < 7 %. CONCLUSIONS: In this large cohort of people with newly diagnosed diabetes, missing HbA1c values was associated with a significantly higher risk of major cardiovascular events or death, more than double the risk observed in people with the worst glycemic control. These findings underscore the clinical importance of routinely recording and monitoring HbA1c at diagnosis, not only as a marker of metabolic control but also as a potential prognostic indicator. The lack of HbA1c may act as an indicator of suboptimal clinical follow-up.

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Orozco‐Beltrán et al. (2025) studied this question.

synapsesocial.com/papers/6a0fc9c82badbc352afeb747https://doi.org/10.1016/j.pcd.2025.11.012
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