Key result
Dabigatran resolves LV thrombus in ~18 days after acute MI in a single case.
Why the study?
Does dabigatran improve the resolution of left ventricular thrombus in patients with acute myocardial infarction?
Case Report (n=1)
No
Does dabigatran improve the resolution of left ventricular thrombus in patients with acute myocardial infarction?
Dabigatran successfully resolved a left ventricular thrombus after acute myocardial infarction in a 78-year-old man, suggesting it may be a viable alternative to warfarin.
May support dabigatran for post-MI LV thrombus resolution; hypothesis-generating case report requiring randomized trials.
Left ventricular thrombus (LVT) after acute myocardial infarction (AMI) is a risk factor for embolic complications. Although warfarin has traditionally been used to treat LVT, it has relevant disadvantages that limit its use. We herein describe the case of a 78-year-old man with AMI who had a history of paroxysmal atrial fibrillation. Following 10 days of urgent coronary reperfusion therapy, transthoracic echocardiography revealed a moderately sized LVT in the apex, which subsequently disappeared after 18 days of treatment with dabigatran. This case demonstrates that dabigatran may represent an alternative to warfarin as a therapeutic option in patients with LVT after AMI.
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Ohashi et al. (2015) conducted a case report in Left ventricular thrombus after acute myocardial infarction (n=1). Dabigatran was evaluated on Resolution of left ventricular thrombus. Dabigatran therapy (110 mg b.i.d.) successfully achieved complete resolution of a left ventricular thrombus after 18 days in a patient with acute myocardial infarction.
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