October 1, 1992Journal of VirologyOpen Access

Constitutive expression of human double-stranded RNA-activated p68 kinase in murine cells mediates phosphorylation of eukaryotic initiation factor 2 and partial resistance to encephalomyocarditis virus growth

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Why the study?

Does expression of human p68 kinase reduce encephalomyocarditis virus growth in murine NIH 3T3 cells?

Population

Murine NIH 3T3 cells

Comparison

Transfection with cDNA encoding… vs Transfection with an inactive mutant possessing…

Design

Preclinical

Authors

ÉMÉliane MeursCentre National de la Recherche Scientifique YWYuichiro WatanabeTokyo University of the Arts SKSuzanne KadereitAlbstadt-Sigmaringen University

Discussion

Member takes

Implication

Does not support clinical translation; extends in vitro evidence for p68 kinase-mediated EMCV resistance in murine cells.

Structured PICO

Does expression of human p68 kinase reduce encephalomyocarditis virus growth in murine NIH 3T3 cells?

Population

Murine NIH 3T3 cells

Intervention

Transfection with cDNA encoding interferon-induced human double-stranded RNA-activated p68 kinase (wild-type)

Comparator

Transfection with an inactive mutant possessing a single amino acid substitution in the invariant lysine 296 in the catalytic domain II

Outcome

Resistance to encephalomyocarditis virus (EMCV) growthsurrogate

Expression of human p68 kinase in murine cells confers partial resistance to EMCV infection via activation and phosphorylation of eIF2.

Cite This Study

Meurs et al. (1992) studied this question.

synapsesocial.com/papers/6a0fe2cfd8c5cf602efd4b5a https://doi.org/10.1128/jvi.66.10.5805-5814.1992

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Constitutive expression of human double-stranded RNA-activated p68 kinase in murine cells mediates phosphorylation of eukaryotic initiation factor 2 and partial resistance to encephalomyocarditis virus growth

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Constitutive expression of human double-stranded RNA-activated p68 kinase in murine cells mediates phosphorylation of eukaryotic initiation factor 2 and partial resistance to encephalomyocarditis virus growth

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider