Why the study?
Antidepressant use is critical for managing mental health disorders, but weight gain is a concerning side effect, prompting investigation of weight changes in Omani patients prescribed specific antidepressants.
Do different antidepressants (paroxetine, fluoxetine, mirtazapine, venlafaxine) cause varying degrees of weight gain in adult patients with mental disorders?
Population
135 adults with mental disorders at Sultan Qaboos University Hospital in Oman
Comparison
Paroxetine vs fluoxetine vs mirtazapine vs venlafaxine
Design
Cross-sectional study
Authors
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Clinicians should monitor weight with paroxetine or mirtazapine; cross-sectional data leaves open causal confirmation.
Do different antidepressants (paroxetine, fluoxetine, mirtazapine, venlafaxine) cause varying degrees of weight gain in adult patients with mental disorders?
In a naturalistic clinical setting, Omani patients taking antidepressants experienced significant weight gain, with paroxetine and mirtazapine causing the most substantial increases.
Al-Jahwari et al. (2025) studied this question.
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