Why the study?
Does the choice of SSRI (fluoxetine, sertraline, or paroxetine) affect weight changes in patients with major depressive disorder?
Population
284 patients with major depressive disorder (DSM-IV)
Comparison
Fluoxetine, sertraline, or paroxetine for 26 to… vs Active comparators
Design
RCT, randomly assigned, double-blind
Follow-up
26 to 32 weeks
Authors
Loading...
Clinicians should favor fluoxetine or sertraline over paroxetine to limit weight gain; confirms differential SSRI effects in MDD.
Does the choice of SSRI (fluoxetine, sertraline, or paroxetine) affect weight changes in patients with major depressive disorder?
Paroxetine is associated with a significantly higher risk of weight gain during extended treatment compared to fluoxetine or sertraline.
Fava et al. (2000) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: