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November 11, 2025Journal of Pharmacology and PharmacotherapeuticsOpen Access

Comparative Real-world Adverse Drug Reactions of Fluoxetine and Sertraline in Outpatients with Depression

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Authors

CWChompoonuch WerawattanachaiPHPattaramart HadeeJSJitapa Sornsoongneon

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Overview

Prospective cross-sectional study finds differences in adverse drug reactions for fluoxetine and sertraline in outpatients with depression, indicating personalized treatment benefits.

Key Points

  • This study aims to evaluate and compare the prevalence of adverse drug reactions (ADRs) associated with fluoxetine and sertraline in outpatients with depression.
  • Conducted a prospective cross-sectional study at a psychiatric hospital
  • Involved 65 outpatients diagnosed with depression on fluoxetine or sertraline
  • Data on ADRs were collected via a validated questionnaire
  • Statistical comparisons used chi-square and Fisher’s exact tests
  • Anorexia was more frequent in the fluoxetine group at 21.28% (p = .05)
  • Nausea/vomiting was more common in the sertraline group at 27.78% (p = .001)
  • ADR profiles included sedation and insomnia as common symptoms
  • No significant differences in gender or treatment duration between groups

Cite This Study

Werawattanachai et al. (2025) studied this question.

synapsesocial.com/papers/69252e90c0ce034ddc3560d0https://doi.org/10.1177/0976500x251390085
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