Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 15, 2025PLoS ONEOpen Access

Safety of antidepressants commonly used in 6–17-year-old children and adolescents: A disproportionality analysis from 2014–2023 on the basis of the FAERS database

View Full Paper
Ask AI
Bookmark
Share

Authors

YZYan ZhouYLYun LuYWYu Wu

Discussion

Loading...

Member takes

Overview

Disproportionality analysis reveals key adverse events in commonly used antidepressants among children and adolescents, suggesting further research is needed.

Key Points

  • Adverse events related to antidepressants show significant patterns in children aged 6–17 years, and involve psychiatric and nervous system issues.
  • The analysis examined 9,845 adverse event reports in the FAERS database, focusing on fluoxetine, escitalopram, and sertraline.
  • Using reporting odds ratio and proportional reporting ratio methods, the study identified key adverse events related to these antidepressants.
  • Findings may highlight previously unreported adverse events, emphasizing the need for ongoing monitoring and research.

Cite This Study

Zhou et al. (2025) studied this question.

synapsesocial.com/papers/68a365600a429f797332b4c7https://doi.org/10.1371/journal.pone.0330025
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pharmacovigilance of SSRIs in Children and Adolescents withDepression: Disproportionality Analysis of Serotonin Adverse EventsUsing the FAERS Database2026
  2. 2Comparative safety of selective serotonin reuptake inhibitors among pediatric users with respect to adverse cardiac events2013 · 21 citations
  3. 3Efficacy and Safety of Escitalopram for Major Depressive Disorder in Children and Adolescents: A Systematic Review and Meta-Analysis with Age-Specific Findings2026
  4. 4Comparative Real-world Adverse Drug Reactions of Fluoxetine and Sertraline in Outpatients with Depression2025
  5. 5The Safety of the Use of Antidepressants: Analysis of the Russian Database of Spontaneous Reports2025