What question did this study set out to answer?

The aim is to evaluate lesion characteristics of a novel temperature-controlled RF ablation system across varying application durations.

June 21, 2023Journal of Interventional Cardiac ElectrophysiologyOpen Access

Characterizing lesion morphology of a novel diamond-tip temperature-controlled irrigated radiofrequency ablation catheter

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Why the study?

Lesion morphologies from longer radiofrequency durations with the novel DiamondTemp ablation system had not been previously described.

Does varying application durations and temperature set-points with the DiamondTemp ablation system affect lesion morphology in an ex vivo porcine model?

Population

280 applications in a bench model using porcine myocardium

Comparison

Temperature set-points of 50 °C vs 60 °C across randomized durations of 5–120 s

Design

Randomized bench model study

Authors

TDTarvinder DhanjalElectrophysiology MSMegan SchmidtMedtronic (United States)MGMichael K. GetmanMedtronic (United States)

Discussion

Member takes

Implication

Ex vivo lesion dimensions plateau after 60 s; leaves open optimal DiamondTemp dosing in humans.

Key Points

The aim is to evaluate lesion characteristics of a novel temperature-controlled RF ablation system across varying application durations.
Bench model using porcine myocardium to deliver discrete lesions in a simulated clinical environment.
DTA system was power-limited at 50 W with temperature set-points of 50 °C and 60 °C.
Application durations ranged from 5 to 120 seconds, with a total of 280 applications performed.
Lesion size increased significantly with longer applications, reaching depth of 4.5 mm (Group_50) and 5.6 mm (Group_60) by 60 s.
Steam pops were noted at longer durations, particularly at 90s and 120s applications.
Depths reached plateaus between 20 to 30 s at 4.6 mm on average.

Structured PICO

Does varying application durations and temperature set-points with the DiamondTemp ablation system affect lesion morphology in an ex vivo porcine model?

Population

Ex vivo bench model using freshly excised porcine right ventricular myocardium

Intervention

DiamondTemp ablation (DTA) system power-limited at 50 W with temperature set-points of 50 °C and 60 °C, application durations randomized from 5 to 120 s

Comparator

Comparison between 50 °C and 60 °C temperature set-points and varying application durations

Outcome

Lesion characteristics including depth, surface width, maximum width, and depth at maximum widthsurrogate

The DiamondTemp ablation system rapidly creates wide lesions with depth plateauing after 60 seconds, suggesting that a 'Time after Temperature 60 °C' approach may optimize ablation dosing.

Limitations

Ex vivo nature lacks cardiac motion and blood flow patterns
Absence of perfused viable myocardium impacts intramuscular cooling and pre-ablation impedance values

Cite This Study

Dhanjal et al. (2023) studied this question.

synapsesocial.com/papers/6a0fe687fa36b6e053fd0239 https://doi.org/10.1007/s10840-023-01595-9

Topics

AF ablation outcomes

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Characterizing lesion morphology of a novel diamond-tip temperature-controlled irrigated radiofrequency ablation catheter

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Topics

Characterizing lesion morphology of a novel diamond-tip temperature-controlled irrigated radiofrequency ablation catheter

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider