Key result
Moderate to vigorous physical activity of more than 60 minutes per day at 12 years of age was independently associated with reduced carotid intima-media thickness at 18 years.
Why the study?
The long-term effects of body composition, physical activity, and cardiorespiratory fitness from puberty on arterial health in late adolescent males were not fully evaluated.
Does cumulative physical activity and cardiorespiratory fitness from puberty to late adolescence improve arterial structure and function in healthy adolescent males?
Cohort (n=102)
Does cumulative physical activity and cardiorespiratory fitness from puberty to late adolescence improve arterial structure and function in healthy adolescent males?
Effect estimate: β = -1.091
p-value: p=0.026
Physical activity at age 12 and cumulative cardiorespiratory fitness through adolescence are independently associated with improved arterial structure (intima-media thickness) at age 18 in healthy males.
May support early MVPA promotion in males; hypothesis-generating for arterial benefits, needs prospective trials.
PURPOSE: To evaluate the long-term effect of body composition, physical activity, and cardiorespiratory fitness (CRF) from puberty on arterial health in late adolescent males. METHODS: The cumulative burden of physical activity (measured with accelerometer), CRF (VO2peak0.82), and body composition (body mass index, fat mass, and fat percentage) from puberty to late adolescence (sum of 4 time points from 12 to 18 y) was assessed in 102 males. Additional analysis on the first (T1) and last (T4) time points was performed. Intima-media thickness (IMT), carotid-femoral pulse wave velocity, and augmentation index adjusted to heart rate of 75 beats per minute (bpm) as dependent variables were measured at T4 and analyzed in multivariable regression models adjusted for known risk factors including maturation, blood pressure, and smoking habits. RESULTS: T1 and cumulative body composition measures were independently associated with IMT, while cumulative (β = -0.011, P = .036) and T4 (β = -0.0.031, P = .001) CRF revealed independent associations with IMT. Individuals with moderate to vigorous physical activity >60 minutes per day at T1 showed relationship (β = -1.091, P = .026) with IMT independently of late adolescent physical activity. No significant relationship was present for arterial function. CONCLUSION: Arterial structure in adolescent males is associated with physical activity at 12 years while relationship with CRF can be seen in late adolescence and cumulatively from puberty to late adolescence.
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Kraav et al. (2022) conducted a cohort in Healthy adolescent males (n=102). Moderate to vigorous physical activity >60 minutes per day vs. <60 minutes per day was evaluated on Intima-media thickness standard score adjusted to height (IMT-SDS) (β = -1.091, p=0.026). Moderate to vigorous physical activity of more than 60 minutes per day at 12 years of age was independently associated with reduced carotid intima-media thickness at 18 years.
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