Why the study?
Does the combined measurement of BNP and N-ANP predict sudden death and heart failure death in patients with chronic heart failure and LVEF <= 35%?
Population
452 patients with chronic heart failure and left ventricular ejection fraction <= 35%
Design
Cohort
Follow-up
up to 3 years
Authors
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May support differential sudden vs HF death risk stratification by BNP/N-ANP in low-LVEF HF; leaves open prospective validation before clinical adoption.
Does the combined measurement of BNP and N-ANP predict sudden death and heart failure death in patients with chronic heart failure and LVEF <= 35%?
Combining BNP and N-ANP measurements allows for distinct risk stratification of sudden death versus progressive heart failure death in patients with chronic heart failure.
Berger et al. (2005) studied this question.
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