Why the study?
Does pravastatin improve carotid intima-media thickness and is it safe in children with familial hypercholesterolemia?
Population
214 children with familial hypercholesterolemia, aged 8 to 18 years, recruited from an academic medical…
Comparison
Pravastatin 20 to 40 mg/d oral added to a… vs Matching placebo tablet added to a…
Design
RCT, Randomly assigned, Double-blind, placebo-controlled
Follow-up
2 years
Authors
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Supports early pravastatin in pediatric familial hypercholesterolemia; extends carotid atherosclerosis regression evidence to children.
Does pravastatin improve carotid intima-media thickness and is it safe in children with familial hypercholesterolemia?
Two years of pravastatin therapy safely induces regression of carotid atherosclerosis in children with familial hypercholesterolemia without adverse effects on growth or sexual maturation.
Wiegman et al. (2004) studied this question.
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