Why the study?
Do statins reduce low-density lipoprotein cholesterol and are they safe in children with heterozygous familial hypercholesterolemia?
Population
1177 children with heterozygous familial hypercholesterolemia across 9 randomized placebo-controlled studies
Comparison
Statins vs Placebo or diet alone
Design
Systematic_review
Follow-up
median 24 weeks; range from six weeks to two years
Authors
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Supports statin use in children with heterozygous familial hypercholesterolemia; confirms short-term LDL-C reduction and safety.
Do statins reduce low-density lipoprotein cholesterol and are they safe in children with heterozygous familial hypercholesterolemia?
Statins effectively reduce LDL-C in children with heterozygous familial hypercholesterolemia and appear safe in the short term, supporting their use while highlighting the need for long-term safety data.
Vuorio et al. (2017) studied this question.
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