Why the study?
Do statins effectively lower LDL-cholesterol and improve endothelial dysfunction in children with familial hypercholesterolemia?
Population
Children with heterozygous familial hypercholesterolemia
Design
Review
Follow-up
up to 2 years (in reviewed trials)
Authors
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Supports short-term statin use in children with familial hypercholesterolemia; leaves open long-term effects on growth and development.
Do statins effectively lower LDL-cholesterol and improve endothelial dysfunction in children with familial hypercholesterolemia?
Statins are effective and safe for lowering LDL-cholesterol in children with familial hypercholesterolemia over 2 years, though longer-term safety data on growth and development are needed.
Serena Tonstad (2003) studied this question.
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