Key result
Higher visceral fat linked to ~22% greater atherosclerosis risk per SD in normal-weight T2D patients.
Why the study?
To investigate the impact of visceral adipose tissue on atherosclerosis in normal-weight type 2 diabetes patients in a Chinese population and evaluate sex-age differences.
Does increased visceral adipose tissue increase the risk of atherosclerosis in type 2 diabetes patients with normal body weight?
Cross-Sectional (n=8,839)
Yes
Does increased visceral adipose tissue increase the risk of atherosclerosis in type 2 diabetes patients with normal body weight?
Effect estimate: OR 1.223 (95% CI 1.065-1.405)
p-value: p=0.004
Increased visceral adipose tissue is an independent risk factor for atherosclerosis, measured by arterial stiffness, in female type 2 diabetes patients with normal body weight.
Visceral fat was associated with atherosclerosis risk in normal-weight T2D; hypothesis-generating and should not yet change practice.
AIMS/INTRODUCTION: To investigate the impact of visceral adipose tissue (VAT) on atherosclerosis in type 2 diabetes patients with normal bodyweight (OB[-]) in the Chinese population, and to further assess the sex-age differences between them. MATERIALS AND METHODS: ): VFA < 100 and BMI < 23.9 (VA[-]OB[-]), VFA < 100 and BMI ≥ 23.9 (VA[-]OB[+]), VFA ≥ 100 and BMI < 23.9 (VA[+]OB[-]), VFA ≥ 100 and BMI ≥ 23.9 (VA[+]OB[+]). Atherosclerosis was defined by brachial-ankle pulse wave velocity (baPWV; cm/s), and we analyzed the association between VFA, BMI and the tertiles of baPWV values. RESULTS: The VA(+)OB(-) prevalence was 3.7% among these participants. Patients with VA(+)OB(-) had the highest baPWV value (P < 0.001) and the highest proportion of the tertile 3 of baPWV (P < 0.001) among four groups, and were significantly associated with baPWV (standardized β = 0.026, P = 0.008). VFA was significantly related to tertile 2 to tertile 3 of baPWV in (OB[-]) type 2 diabetes patients, when compared with tertile 1 of baPWV, respectively. In sex-age stratified analysis, the association of VFA and the tertiles of baPWV showed sex differences. For the 55 years age stratification analysis, there was no age difference in the relationship between VFA and baPWV in (OB[-]) patients. CONCLUSION: Increased VAT was an independent risk factor for atherosclerosis in female type 2 diabetes patients with normal weight.
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Xu et al. (2022) conducted a cross-sectional in Type 2 diabetes with normal bodyweight (n=8,839). Increased visceral adipose tissue (VFA ≥ 100 cm2) vs. Normal visceral adipose tissue (VFA < 100 cm2) was evaluated on Atherosclerosis (highest vs lowest tertile of brachial-ankle pulse wave velocity) (OR 1.223, 95% CI 1.065-1.405, p=0.004). A standard deviation increment in visceral fat area was significantly associated with an increased risk of atherosclerosis (OR 1.223) in type 2 diabetes patients with normal body weight.
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