Key result
Visceral fat area was independently associated with decreased LVEF (β = -0.096, p=0.010), increased LVMI (β = 0.083, p=0.038), and increased baPWV (β = 0.120, p=0.003) in women with T2DM, but not men.
Why the study?
To analyze the associations among fat distribution, left ventricular structure, and function in T2DM patients and assess sex differences among them.
Is visceral fat area differentially associated with left ventricular structure and function in male versus female patients with type 2 diabetes?
Cross-Sectional (n=2,107)
Is visceral fat area differentially associated with left ventricular structure and function in male versus female patients with type 2 diabetes?
Effect estimate: β = -0.096
p-value: p=0.010
Visceral fat area is independently associated with worse left ventricular ejection fraction, increased left ventricular mass index, and increased arterial stiffness in female, but not male, patients with type 2 diabetes.
Suggests sex-specific visceral fat effects on cardiac parameters in T2D; hypothesis-generating and should not yet change practice.
Background The aim of this study is to analyze the associations among fat distribution, left ventricular (LV) structure, and function in T2DM patients and further assess the sex differences among them. Methods Two thousand and one hundred seven T2DM patients were enrolled to this study. Patients' height, weight, BMI, visceral fat area (VFA), baPWV, parameters of cardiac structure and function, and clinical biochemical indicators were measured and collected. Results There were significant differences between male and female T2DM patients in age, duration of diabetes, complication ratio of hypertension and dyslipidemia, smoking history, visceral fat, baPWV, and ventricular structure and function ( p < 0.05). Compared with the Q1 group, female patients in the highest quartile (Q4) of VFA had a decreased LVEF and significantly increased baPWV ( p < 0.05), whereas no such changes were found in males. The correlation analysis showed that LVEF in male patients was negatively correlated with hypertension history, using of CCBs, GLP‐1RA, lipid‐lowering medications, BMI, WC, WHR, FPG, FC‐P, HbA1c, GA, HOMA‐IR, Cr, and baPWV, while the LVEF in female patients was negatively correlated with VFA, VSR, VFA/BMI, VFA/H 2 , VFA/weight in females ( p < 0.05). LVMI was positively associated with diabetes duration, age, hypertension history, WC, WHR, VFA, SFA, VFA/BMI, VFA/H 2 , VFA/weight, and baPWV in both males and females. Multivariable‐adjusted linear regression analysis showed that VFA was independently associated with LVEF ( β = − 0.096, p = 0.010), LVMI ( β = 0.083, p = 0.038), and baPWV ( β = 0.120, p = 0.003) in females. Conclusions Values of VFA were independently associated with LVEF, LVMI, and baPWV in women, but not in men, in patients with T2DM.
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Rui‐hua et al. (2024) conducted a cross-sectional in Type 2 diabetes (n=2,107). Visceral fat area (VFA) vs. Lower VFA was evaluated on Left ventricular ejection fraction (LVEF) (β = -0.096, p=0.010). Visceral fat area was independently associated with decreased LVEF (β = -0.096, p=0.010), increased LVMI (β = 0.083, p=0.038), and increased baPWV (β = 0.120, p=0.003) in women with T2DM, but not men.
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