Why the study?
Although cardiac resynchronization therapy improves LVEF in chronic heart failure guidelines, whether it has a role in acute heart failure syndromes remains an open question.
Does cardiac resynchronization therapy improve LVEF and clinical outcomes in a patient with cardiogenic shock and a widened QRS?
Does cardiac resynchronization therapy improve LVEF and clinical outcomes in a patient with cardiogenic shock and a widened QRS?
Cardiac resynchronization therapy may serve as a potential rescue therapeutic option for patients with cardiogenic shock and a widened QRS who fail optimal medical management.
Hypothesis-generating for CRT rescue in refractory cardiogenic shock with wide QRS; prospective trials needed before adoption.
Cardiac resynchronization therapy (CRT) has consistently proven its capability to improve the left ventricular ejection fraction (LVEF). The benefits and indications for this therapy have been elucidated in current heart failure guidelines. However, it remains a topic of discussion if there is a role for it in acute heart failure syndromes (AHFSs). We present the case of a 55-year-old male with a medical history of alcohol-induced cardiomyopathy presenting with a new left bundle branch block, a widened QRS (154 ms), and cardiogenic shock (CS). After a lack of improvement with optimal medical management, CRT was used as a last resort. After implantation, the patient had a satisfactory clinical course and the LVEF improved. At the four-month follow-up, he underwent an outpatient transthoracic echocardiogram with further augmentation of his LVEF, improvement of his functional class, and no reported acute heart failure events. This case illustrates a potential therapeutic option for CS with a widened QRS. Prospective trials should include AHFSs to clarify the utility of CRT in this patient population.
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Somoza-Cano et al. (2021) studied this question.
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