Cardiac resynchronization therapy in chronic heart failure
View Full Paper
Ask AI
Bookmark
Share
Key result
CRT reduces mortality and improves LV function vs medical therapy in severe HF with dyssynchrony.
Why the study?
Does cardiac resynchronization therapy improve outcomes in patients with severe, drug-refractory heart failure and signs of intraventricular dyssynchrony?
Population
Patients with severe, drug-refractory heart failure and signs of intraventricular dyssynchrony
Comparison
Cardiac resynchronization therapy (CRT) vs Optimized medical therapy alone
Design
Review
Authors
Discussion
Loading...
Member takes
Implication
May support CRT in severe HF with dyssynchrony; leaves open optimal selection and programming.
Structured PICO
Does cardiac resynchronization therapy improve outcomes in patients with severe, drug-refractory heart failure and signs of intraventricular dyssynchrony?
P
Population
Patients with severe, drug-refractory heart failure and signs of intraventricular dyssynchrony.
I
Intervention
Cardiac resynchronization therapy (CRT)
C
Comparator
Optimized medical therapy alone
This review summarizes evidence that CRT reduces morbidity and mortality in symptomatic heart failure patients with intraventricular dyssynchrony, while highlighting ongoing challenges in patient selection and device programming.
Limitations
- Identifying the 20-30% of patients who will not respond to CRT
- Uncertainty regarding CRT in patients with atrial fibrillation or chronic right ventricular stimulation
- Role of a back-up defibrillator remains an individual decision
Cite This Study
Sticherling et al. (2006) conducted a review in chronic heart failure. Cardiac resynchronisation therapy (CRT) vs. optimised medical therapy alone was evaluated. Cardiac resynchronisation therapy reduces overall mortality, improves symptoms, exercise tolerance, and left ventricular function compared with optimised medical therapy alone in patients with severe heart failure and intraventricular dyssynchrony.
Topics
View Full Paper
Ask AI
Bookmark
Share