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February 11, 2016Expert Review of Clinical ImmunologyOpen Access

The role of Bruton’s tyrosine kinase in autoimmunity and implications for therapy

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Authors

LCLeslie J. CroffordLNLindsay E. NyhoffJSJonathan H. Sheehan

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Crofford et al. (2016) studied this question.

synapsesocial.com/papers/6a0ff27d5725bbd5cc604a37https://doi.org/10.1586/1744666x.2016.1152888
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A phosphorylation site in Bruton's tyrosine kinase selectively regulates B cell calcium signaling efficiency by altering phospholipase C-γ activation2004 · 18 citations
  2. 2Reduced Dosage of Bruton’s Tyrosine Kinase Uncouples B Cell Hyperresponsiveness from Autoimmunity in lyn −/− Mice2003 · 49 citations
  3. 3Ability of the xid gene to prevent autoimmunity in (NZB X NZW)F1 mice during the course of their natural history, after polyclonal stimulation, or following immunization with DNA.1982 · 129 citations