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May 22, 2026Environment InternationalOpen Access

Beneficial roles of selenium and docosahexaenoic acid against prenatal methylmercury–induced adverse effects on child neurodevelopment: The Tohoku Study of Child Development at 42 months

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Authors

NTNozomi TatsutaNational Institute for Environmental StudiesMIMiyuki Iwai-ShimadaNational Institute for Environmental StudiesSNShoji F. NakayamaNational Institute for Environmental Studies

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Implication

Randomized trial demonstrates the effects of prenatal exposure on cognitive outcomes in children, indicating nutrient balance is crucial.

Key Points

  • This study aims to investigate the effects of prenatal exposure to methylmercury, DHA, and selenium on child cognitive development at 42 months of age.
  • Examined 471 children aged 42 months for associations between MeHg, DHA, Se, and IQ using K-ABC.
  • Evaluated biomarker levels of maternal hair total mercury, plasma DHA, and cord plasma selenium.
  • Used multiple regression, Bayesian kernel machine regression (BKMR), and quantile g-computation for analysis.
  • Maternal hair total mercury negatively impacted simultaneous and mental processing scores in males (p<0.05).
  • Maternal plasma DHA showed a positive association with mental processing scores in males (p<0.05).
  • Cord-plasma selenium demonstrated marginal positive impacts on cognitive scores for males, but no definitive overall association was found.

Cite This Study

Tatsuta et al. (2026) studied this question.

synapsesocial.com/papers/6a0ff2a8d674f7c03778b304https://doi.org/10.1016/j.envint.2026.110313
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cognitive Deficit in 7-Year-Old Children with Prenatal Exposure to Methylmercury1997 · 1,744 citations
  2. 2Effect of DHA Supplementation During Pregnancy on Maternal Depression and Neurodevelopment of Young Children2010 · 564 citations
  3. 3Fluorometric Determination of Selenium in Biological Material with 2,3-Diaminonaphthalene.1966 · 675 citations
  4. 4Bayesian kernel machine regression for estimating the health effects of multi-pollutant mixtures2014 · 1,883 citations
  5. 5Maternal dietary intake of fish and PUFAs and child neurodevelopment at 6 months and 1 year of age: a nationwide birth cohort—the Japan Environment and Children’s Study (JECS)2020 · 45 citations