What question did this study set out to answer?

To report an isolated case of episcleral ALK-positive histiocytosis in an adult and its diagnosis through ALK gene rearrangement.

May 22, 2026Orbit

Localized episcleral ALK-positive histiocytosis: a novel adult presentation confirmed by ALK gene rearrangement

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Case report demonstrates isolated episcleral ALK-positive histiocytosis in an adult, suggesting a need for routine screening.

To report an isolated case of episcleral ALK-positive histiocytosis in an adult and its diagnosis through ALK gene rearrangement.
Excisional biopsy performed on an episcleral nodule.
Immunohistochemistry conducted to assess ALK1 expression and other markers.
Whole-body PET-CT used to identify additional suspicious nodes.
Excisional biopsy revealed sheets of foamy CD68+/CD163+ histiocytes with giant cells.
Fluorescence in situ hybridization confirmed ALK gene rearrangement in 60% of nuclei.
Symptomatic improvement observed after initiating treatment with alectinib.

Abraham et al. (2026) studied this question.

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