Review highlights vaccine safety and efficacy in individuals with Down syndrome, suggesting improvements in response.
Although individuals with Down syndrome (DS) remain highly vulnerable to severe infections, vaccination remains underutilized. Here we review, specific to people with DS, the safety and efficacy of vaccination, drivers of susceptibility to infection, and existing and emerging opportunities to improve vaccine response. We find that vaccines are generally safe and immunogenic in individuals with DS, although continued research is essential to improve vaccine efficacy and health outcomes.
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Khor et al. (2026) studied this question.
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