Identifies covalent inhibitors of actin maturation protease in cancer cells, suggesting new chemical probe strategies.
-terminally unprocessed actin in cancer cells. Our findings support reactive group diversification as a strategy for expanding the ligandability of the human proteome and the butynamide, more specifically, as a differentiated cysteine-directed electrophile for chemical probe discovery.
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Xiong et al. (2026) studied this question.
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