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May 22, 2026Journal of Clinical MedicineOpen Access

Interferon-γ and Interleukin-10 Profiles Correlate with Disease Severity in Sudanese Children with Plasmodium falciparum Malaria

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Authors

THTassneem Awad HajaliMMMuna Ismail Elmisbah MekkiNANouralsalhin A. Alaagib

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Overview

Case-control study evaluates cytokine levels to distinguish severe malaria in Sudanese children, suggesting potential diagnostic use.

Key Points

  • This study assesses the relationship between IFN-γ and IL-10 levels and disease severity in Sudanese children with P. falciparum malaria.
  • Conducted a hospital-based case-control study with 105 children divided into severe malaria, uncomplicated malaria, and healthy control groups.
  • Measured plasma levels of IFN-γ and IL-10 using ELISA.
  • Analyzed correlations between cytokine levels and hematological parameters.
  • Elevated levels of IFN-γ and IL-10 were significantly associated with severe malaria compared to uncomplicated malaria and healthy controls (p < 0.001).
  • A strong positive correlation between IFN-γ and IL-10 was observed (rho = 0.688, p < 0.001).
  • IL-10 and IFN-γ demonstrated moderate diagnostic performance for distinguishing severe from uncomplicated malaria (AUC = 0.687).

Cite This Study

Hajali et al. (2026) studied this question.

synapsesocial.com/papers/6a0ff33bd674f7c03778bc35https://doi.org/10.3390/jcm15103929
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