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May 20, 2026Organic Letters

Enantioselective Synthesis of Chiral Dihydroisobenzofurans via Tandem Asymmetric Hydrogenation and Selective Oxo-cyclization

Kejia Yang Nan Li Zhonghao Geng Zheng Yang Gongming Zhu Qingyang Zhao

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Key Points

To develop a method for the enantioselective synthesis of chiral dihydroisobenzofurans using tandem asymmetric hydrogenation and selective oxo-cyclization.
Used tandem asymmetric hydrogenation and oxo-cyclization to create chiral compounds.
Explored the roles of metal and base in maximizing efficiency.
Demonstrated operational simplicity in the synthesis process.
Achieved high enantioselectivity and efficiency in creating chiral dihydroisobenzofurans.
Identified dual roles of metal and base contributing to improved synthesis.
Established a new synthetic pathway for complex molecular structures.

Implication

Shows efficient synthesis of chiral dihydroisobenzofurans, indicating potential for complex molecule production.

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Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/6a0ff362d674f7c03778c04f https://doi.org/10.1021/acs.orglett.6c01241

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