Why the study?
The current concept of primary sudden cardiac death prevention based on heart failure severity and left ventricular dysfunction is not effective enough, requires mass implantable defibrillator use, and has low predictive accuracy for life-threatening arrhythmias.
Incorporating myocardial imaging for fibrosis and medical genetics may refine indications for primary prevention ICDs beyond current LVEF-based criteria.
The article covers the development of the problem of sudden cardiac death prevention with the implantable cardioverter-defibrillators from the moment of creation of these devices to our days. The current concept of primary prevention of sudden cardiac death, based on the severity of manifestation of heart failure and left ventricular dysfunction, is not effective enough. Its practical application is difficult because it requires mass application of implantable defibrillators, with low predictive accuracy of these criteria in terms of development of life-threatening arrhythmias. The development of methods for visualizing the myocardium, allowing to assess the severity of myocardial fibrosis, as well as the possibilities of medical genetics, at the present stage, allows us to clarify indications for implantation of cardioverter-defibrillators and thereby significantly improve the concept of preventing sudden cardiac death with these instruments.
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Bokeria et al. (2018) studied this question.
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