Intramolecular Oxidative C(sp3)-N Coupling Towards Pyrrolidine and Piperidine with Catalytic Amount of Iodoform

Shaoqun Zhu; Siwen Chen; Huaguang Yu; Pengpeng Zhu; Mengyan Gao; Linyang Jiang; Tong Liu; Ying Han; Hong Hou

doi:10.1039/d6cc02334g

January 1, 2026Chemical Communications

Intramolecular Oxidative C(sp3)-N Coupling Towards Pyrrolidine and Piperidine with Catalytic Amount of Iodoform

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Key Points

The central aim is to develop an oxidative intramolecular C(sp3)-N bond coupling for synthesizing nitrogen-containing heterocycles.
Utilized a catalytic amount of iodoform under visible-light irradiation.
Applied oxidative conditions to facilitate the coupling reaction.
Focused on the synthesis of pyrrolidine and piperidine derivatives.
Successfully synthesized nitrogen-containing heterocycles using the proposed method.
Displayed notable efficiency under the specified reaction conditions.

Implication

Demonstrates a new method for synthesizing nitrogen-containing heterocycles using iodoform.

Abstract

We reported herein an oxidative intramolecular C(sp3)-N bond coupling reaction for the synthesis of nitrogen-containing heterocycles with a catalytic amount of iodoform under the visible-light irradiation conditions, providing a novel...

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Cite This Study

Zhu et al. (2026) studied this question.

synapsesocial.com/papers/6a0ff38cd674f7c03778c3b2 https://doi.org/10.1039/d6cc02334g

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Intramolecular Oxidative C(sp3)-N Coupling Towards Pyrrolidine and Piperidine with Catalytic Amount of Iodoform

Key Points

Implication

Abstract

Discussion

Cite This Study

Intramolecular Oxidative C(sp3)-N Coupling Towards Pyrrolidine and Piperidine with Catalytic Amount of Iodoform

Key Points

Implication

Abstract

Discussion

Cite This Study

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