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May 22, 2026Journal of Medical Society

Burden beyond the bone: Quality of life impacts and clinical challenges in bone cancer progression and metastasis

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Authors

MKMithilesh KumarJRJaishriram RathoredTBTanushree Budhbaware

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Overview

Review highlights how molecular mechanisms impact osteosarcoma metastasis and treatment challenges, suggesting future therapeutic strategies.

Key Points

  • This review aims to explore the molecular mechanisms underlying osteosarcoma metastasis and their implications for treatment.
  • Literature review and data evaluation using various search engines to identify biological components of metastasis.
  • Analysis of SPARC recombinants and SPARC-deficient mice to understand integrin-mediated tumor migration.
  • Assessment of the VEGF/VEGFR-2 signaling loop effects on tumor cell growth and angiogenesis.
  • SPARC enhances metastatic behavior through activation of integrins αVβ3 and αVβ5, facilitating cell migration.
  • VEGF/VEGFR-2 signaling loop provides advantages for tumor survival and promotes angiogenesis.
  • Targeting integrin-mediated pathways and ECM modulation shows potential for improving treatment outcomes.

Cite This Study

Kumar et al. (2026) studied this question.

synapsesocial.com/papers/6a0ff3ffd674f7c03778d05ehttps://doi.org/10.4103/jms.jms_64_25
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