What question did this study set out to answer?

The aim is to document a rare case of B/T mixed phenotype acute leukemia with BCR-ABL1 rearrangement.

May 22, 2026

Mixed Phenotype Acute Leukemia with B/T Lineage and BCR-ABL1 Rearrangement: a Case Report and Literature Review

HMHassane MamadMohammed V University HSHamza SiyarMohammed V University JZJalila Zirar

Key Points

The aim is to document a rare case of B/T mixed phenotype acute leukemia with BCR-ABL1 rearrangement.
Patient presented with hemorrhage, infection, and hemodynamic instability.
Laboratory analysis showed bicytopenia and leukocytosis, and immunophenotyping identified B and T lineage.
Fluorescence in situ hybridization was used to confirm BCR-ABL1 rearrangement.
Diagnosis confirmed as B/T MPAL with BCR-ABL1 rearrangement.
The patient achieved complete remission using tyrosine kinase inhibitors, following the GRALL-2014 protocol.
Patient is awaiting matched sibling donor transplantation.

Abstract

BACKGROUND: We report a case of B/T mixed phenotype acute leukemia (MPAL) with BCR-ABL1 rearrangement in a 35-year-old male presenting with hemorrhage, infection, and hemodynamic instability. METHODS: Laboratory findings showed bicytopenia (hemoglobin 79 g/L, platelets 17 x 10⁹/L), leukocytosis (7.7 x 10⁹/L). Peripheral blood and bone marrow smears showed 22% and 66% myeloperoxidase-negative blasts, respectively. Immunophenotyping identified coexisting T-lineage (cytoplasmic CD3+, CD2+, CD5+) and B-lineage (CD19+, CD79a+, cytoplasmic IgM+) populations. Fluorescence in situ hybridization confirmed BCR-ABL1. RESULTS: The diagnosis for our case was B/T MPAL with BCR-ABL1 rearrangement. The patient achieved com-plete remission with tyrosine kinase inhibitors per GRALL-2014 protocol and is awaiting matched sibling donor transplantation. CONCLUSIONS: This case demonstrates the diagnostic complexity and aggressive nature of BCR-ABL1-positive B/T MPAL.

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