What question did this study set out to answer?

To evaluate whether nasal continuous positive airway pressure (NCPAP) improves cardiac function and sleep-disordered breathing in patients with congestive heart failure and Cheyne-Stokes respiration.

January 1, 1995American Journal of Respiratory and Critical Care Medicine

Treatment of Congestive Heart Failure and Cheyne-Stokes Respiration during Sleep by Continuous Positive Airway Pressure

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Why the study?

Does nightly nasal continuous positive airway pressure improve left ventricular ejection fraction in patients with congestive heart failure and Cheyne-Stokes respiration with central sleep apnea?

Population

29 patients with congestive heart failure and Cheyne-Stokes respiration with central sleep apnea receiving…

Comparison

Nightly nasal continuous positive airway… vs Control group receiving optimal medical therapy.

Design

RCT, randomly assigned

Follow-up

3 months

Authors

MNMatthew T. NaughtonThe Alfred Hospital PLP P Liu DBDW BernardJohns Hopkins University

Discussion

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Implication

NCPAP may improve LVEF in HF with Cheyne-Stokes respiration and central sleep apnea; extends RCT evidence for treating sleep-disordered breathing in this population.

Key Points

To evaluate whether nasal continuous positive airway pressure (NCPAP) improves cardiac function and sleep-disordered breathing in patients with congestive heart failure and Cheyne-Stokes respiration.
Conducted a randomized controlled trial in 29 patients with congestive heart failure and Cheyne-Stokes respiration with central sleep apnea receiving optimal medical therapy.
Participants were randomly assigned to nightly NCPAP (n = 14) or a control group (n = 15) over a 3-month follow-up period, with 12 patients completing the study in each arm.
NCPAP significantly increased left ventricular ejection fraction compared with control (mean ± SEM: 7.7 ± 2.5% vs. -0.5 ± 1.5%, p = 0.019).
Nightly NCPAP led to a significantly greater reduction in the frequency of apneas and hypopneas compared to control (-28.5 ± 3.9 vs. -6.1 ± 7.0 events per hour of sleep, p = 0.012).
Patients receiving NCPAP experienced significant improvements in fatigue symptoms (5.6 ± 1.2 vs. 0.8 ± 0.7, p = 0.005) and disease mastery (3.6 ± 1.1 vs. -0.7 ± 0.7, p = 0.031).

Structured PICO

Does nightly nasal continuous positive airway pressure improve left ventricular ejection fraction in patients with congestive heart failure and Cheyne-Stokes respiration with central sleep apnea?

Population

29 patients with congestive heart failure (CHF) and Cheyne-Stokes respiration with central sleep apnea (CSR-CSA) receiving optimal medical therapy.

Intervention

Nightly nasal continuous positive airway pressure (NCPAP) added to optimal medical therapy for 3 months.

Comparator

Control group receiving optimal medical therapy.

Outcome

Left ventricular ejection fraction (LVEF) over a 3-month period.surrogate

Nightly NCPAP improves left ventricular ejection fraction, attenuates sleep apnea, and alleviates symptoms in patients with heart failure and Cheyne-Stokes respiration.

Cite This Study

Naughton et al. (1995) studied this question.

synapsesocial.com/papers/6a0ff5ae64e8141cd25fed0e https://doi.org/10.1164/ajrccm.151.1.7812579

Topics

HFrEF treatment Heart failure

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Implication

NCPAP may improve LVEF in HF with Cheyne-Stokes respiration and central sleep apnea; extends RCT evidence for treating sleep-disordered breathing in this population.

Treatment of Congestive Heart Failure and Cheyne-Stokes Respiration during Sleep by Continuous Positive Airway Pressure

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Treatment of Congestive Heart Failure and Cheyne-Stokes Respiration during Sleep by Continuous Positive Airway Pressure

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider