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November 27, 2013Stem Cell ReportsOpen Access

Common Developmental Pathway for Primitive Erythrocytes and Multipotent Hematopoietic Progenitors in Early Mouse Development

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Authors

TYToshiyuki YamaneAWAya WashinoHYHidetoshi Yamazaki

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Overview

Laboratory study reveals bipotential progenitors producing primitive erythrocytes and lymphomyeloid cells in mouse embryos, indicating shared lineage origins prior to hematopoietic stem cell...

Key Points

  • To clarify the developmental lineage relationships between transient primitive erythrocytes and subsequent multilineage lymphohematopoietic cells in early embryos.
  • Analyzed differentiating embryonic cells derived from mouse embryonic stem cell cultures and developing mouse embryos.
  • Assessed the developmental potential of single isolated cells characterized by the surface phenotype CD45(-)CD41(+)AA4.1(-).
  • Identified CD45(-)CD41(+)AA4.1(-) cells as bipotential progenitors capable of generating both primitive erythrocytes and lymphomyeloid cells at the single-cell level.
  • Demonstrated that these shared precursor populations are present in vivo before the emergence of definitive hematopoietic stem cells.

Cite This Study

Yamane et al. (2013) studied this question.

synapsesocial.com/papers/6a0ff75705c0aeebb1fe15c1https://doi.org/10.1016/j.stemcr.2013.10.008
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